Medication & Fragile X

Children and adults with fragile X syndrome often present a variety of behavioral problems. These problems are typically seen in fragile X syndrome so they are presumed to be caused by a lack or a deficiency of normal FMR-1 protein (FMRP) production from the FMR1 gene which is dysfunctional in fragile X syndrome. Although there is presently no cure for fragile X syndrome, there are a variety of medications that can improve the behavior problems seen in fragile X syndrome. Not every fragile X child will have difficulty with the behaviors and not every child will respond to medication. When problems occur, a medication is usually prescribed on a trial basis and often two or more trials of medication are needed before finding one that works. Sometimes more than one medication is used to treat a combination of problems and sometimes medications are used together for a more effective outcome.  An open line of communication along with follow up visits is needed in order to adjust the medication level and monitor the side effects.

It is important to remember that medication is not the only treatment for fragile X syndrome. *The use of therapy in the motor and language areas and special education intervention are essential in the treatment program for a child with fragile X syndrome. In addition, counseling and behavior modification programs with positive reinforcement can be extremely important for children with significant behavior problems.

*Some of the more common behavior problems that respond to medication include: hyperactivity, impulsive behavior, attention difficulties, mood fluctuations, aggressive outbursts, anxiety and obsessive or compulsive behavior.